REF SEMAX-VIAL-10MG

Semax

Research-grade Semax peptide (99% purity, HPLC-verified).

Semax is a synthetic research peptide used to study neuroplasticity, cognitive function, stress-response pathways, and neuroprotection in experimental models. It is high-purity, HPLC-verified, and provided as a lyophilized powder.

Supports neuroplasticity research
Modulates neurotransmitter pathways in models
Used in stress and ischemia research models

Size 10 mg

5 mg 10 mg

299.25 AED

Formula: C37H51N9O10S

M.W.: 813.9 g/mol

Verified View Verified COA

Verification: Assay 99.0% · Lab: BTL Labs – Independent third-party analytical testing.

PURITY HPLC tested RUO

All information is for educational and research purposes only. Not advice or recommendations.

Boosts brain growth signals

Elevates brain-derived neurotrophic factor (BDNF) and TrkB activity in the rat basal forebrain. [PubMed]
Supports brain recovery

Semax suppresses post-ischemic inflammatory proteins and activates CREB-mediated recovery signaling in a rat cerebral ischemia-reperfusion model. [PubMed]
Sharper focus & memory

Semax activates neurotransmission-related gene expression and counteracts ischemia-driven suppression of neural signaling in rat brain models. [PubMed]
Protects brain cells

Modulates neurotrophic and anti-apoptotic gene expression implicated in neuronal survival. [PubMed]
Calms the stress response

A non-hormonal ACTH 4-10 derivative with documented anxiolytic and stress-buffering effects in animal models. [PubMed]

Semax is a synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH) with the amino acid sequence Met-Glu-His-Phe-Pro-Gly-Pro. Developed by researchers at the Russian Academy of Sciences in the early 1990s, it has been studied for neuroprotective and cognitive-enhancing properties.

Mechanism (preclinical)

Semax is a small research peptide modeled after an ACTH fragment. In preclinical studies, it appears to support brain signaling by boosting BDNF (a key neuroplasticity protein), modulating dopamine and serotonin pathways, and interacting with melanocortin receptors involved in stress response. It may also help protect neurons by reducing oxidative stress. These effects are observed only in experimental settings.

Sequence

Met-Glu-His-Phe-Pro-Gly-Pro

Molecular Formula

C37H51N9O10S

Molecular Weight (g/mol)

—

PubChem

CID 9811102

Neuroplasticity & BDNF Pathways1

Semax is widely used in research exploring neuroplasticity—the brain’s ability to adapt, reorganize, and form new connections. Preclinical models show that Semax may increase the expression of BDNF (Brain-Derived Neurotrophic Factor) and its receptor TrkB. These pathways are central to learning, memory formation, and neural resilience. Researchers often use Semax when studying molecular signaling related to synaptic modulation and neuronal recovery.

Source

Stress Response & Neuroprotective Effects2

Semax is also studied for its potential role in stress-response pathways and cellular protection mechanisms. Research models suggest it may modulate melanocortin receptors and influence dopamine and serotonin systems involved in stress regulation. Additional studies explore Semax for its antioxidant activity and ability to support neurons under ischemic or hypoxic conditions, making it a common choice in neuroprotection research.

Source

Neurotransmitter Modulation3

Semax is frequently used in studies examining dopamine and serotonin pathways. Preclinical data suggest it may influence monoaminergic turnover, receptor sensitivity, and downstream gene expression involved in attention, motivation, and stress adaptation. These models help researchers explore how neuropeptides regulate chemical signaling in the brain.

Source

Ischemia & Hypoxia Research Models4

Semax is widely used in laboratory models simulating reduced oxygen or blood flow to brain tissue. These studies focus on neuroprotection, inflammation pathways, oxidative stress markers, and recovery processes. Semax’s influence on antioxidant activity and gene expression makes it a frequent candidate in ischemia and hypoxia research.

Source

Research Use

Certificate of Analysis

Verified (independent lab) Last verified: Nov 5, 2025

View COA

COA archive

COA (image)

COA – Semax (Batch SID-005000036603221, Assay 2025-11-05, Lab BT Labs, v1.0.0)

HPLC

Quality & Testing ≥99% purity HPLC verified Batch COA available

Lyophilized research peptide.

Verified View Verified COA

Form: Lyophilized peptide powder.

Storage: Store the lyophilized powder at 4 °C for short-term or −18 °C for long-term stability. Once reconstituted, keep refrigerated at 2–8 °C and use within 2–7 days. Avoid repeated freeze–thaw cycles.

Reconstitution: Use sterile or bacteriostatic water. Add slowly along the vial wall and allow the powder to dissolve by gentle swirling—do not shake vigorously. Prepare only the amount needed for immediate research use.

This peptide is supplied strictly for laboratory research use only (RUO). Not for human use, clinical use, veterinary use, or diagnostic applications.

Do not ingest, inject, inhale, or apply to skin. Not a food, supplement, drug, or cosmetic. For trained professionals in research settings only.

For laboratory research use only. Not for human consumption. Use appropriate PPE and handle in a controlled environment.

For laboratory research use only. Not for human consumption. No therapeutic claims.

Frequently Asked Questions

What is Semax?

Semax is a synthetic research peptide modeled after a short segment of the ACTH (adrenocorticotropic hormone) sequence. It is used in experimental settings to study neuroplasticity, cognitive pathways, and stress-response signaling.

How should Semax be stored?

Store lyophilized Semax in a cool, dry environment away from light. For extended stability, refrigeration is recommended. After reconstitution, follow your laboratory’s storage protocols and use sterile technique.

How is Semax supplied?

Semax is supplied as a lyophilized powder in a sealed amber research vial. It must be reconstituted using sterile or bacteriostatic water depending on the study design.

What purity and verification does Semax have?

Each batch is ≥99% purity and is verified using third-party HPLC and FTIR analysis. Every vial includes a batch-specific COA confirming identity, purity, and composition.

How should Semax be handled in research settings?

Handle Semax using appropriate PPE inside a controlled laboratory environment. Do not ingest, inject, inhale, or apply to skin. Reconstitute and use only under sterile, research-grade conditions.

Referenced Citations

pubchem.ncbi.nlm.nih.gov →
PubMed pubchem.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov →
PubMed pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov →
PubMed pubmed.ncbi.nlm.nih.gov
alzdiscovery.org →
alzdiscovery.org

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Because delicate amino acid chains can degrade quickly in extreme temperatures, our logistics team utilizes strict protocols for shipping peptides safely in UAE heat to guarantee product stability upon arrival.